Antigen-bound IgM activates the C1 complex

Classical pathway, complement activation: antigenmagenta-bound immunoglobulin M IgM, light blue activates the C1 complex violet. Source: PDB entries 7k0c, 1cgd, 5hkj, 6f1c

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Keywords: activation antibody classical complement complex defense disease epitope igm illness immune immunization immunoglobulin immunology infectious pathway protease protein system vaccination zymogene

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