High level of RBC and platelet in Polycythemia vera (PV) - closeup view 3d illustration
In oncology, polycythemia vera (PV) is an uncommon myeloproliferative neoplasm in which the bone marrow makes too many red blood cells. The majority of cases are caused by mutations in the JAK2 gene, most commonly resulting in a single amino acid change in its protein product from valine to phenylalanine at position 617.
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polycythemiaveraoncologyhematologymyeloproliferativeneoplasmbonemarrowredbloodcellsmutationsjak2erythroidmegakaryocyticgranulocyticpanmyelosistyrosinekinasehormoneerythropoietinepogeneaminoacidvalinephenylalaninethickerswellinginflammationitchingpruritusburningpainhandsfeetreddishbluishcolorationgoutyarthritisphlebotomychemotherapyinterferonhyperviscosityhistamineprostaglandinpepticulcerdiseasehelicobacterpyloricampylobacteressentialthrombocythemiaerythromelalgiaclotsplateletcountcardiovascularproteinarteryreceptor
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